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  3. Michael N. N. Nartey

Dr. Michael N. N. Nartey

Research Scientist

Office : CSIR ARI Room 22

Email :

Degrees : B.Sc. (UCC, Ghana), MSc (Shimane University, Japan), PhD (Tottori University, Japan)

Achievements

Awards and Recognition
  • 2014 – 2020: Japanese Government (Monbukagakusho: MEXT) Scholarship

    • Research

    Research Interests
  • Biochemistry and molecular cell biology for food, nutrition, nutraceutical, pharmaceutical, and health.
  • Utilization of bacteriophage in fight against antimicrobial resistance.
  • Vaccine development.
    • Brief Profile

    Dr. Michael Nartey is a biochemist with research expertise in Lipid Biochemistry and Molecular Cell Biology. He holds a BSc degree in Human biology from the University of Cape Coast, an MSc degree in Life and Environmental Science (Biological Science and Biotechnology) from Shimane University, Japan and completed his PhD in Bioresources Science (Biochemistry and Molecular Cell Biology) from Tottori University, Japan through the support of the Japanese Government (MEXT) Scholarship. During his graduate studies, he worked as a Graduate Research Assistant in Shimane University where he managed lab operations, trained and supervised undergraduate, graduate and European internship students in safe laboratory research and maintenance procedures. His research interest is in the biochemistry and molecular cell biology of food, nutrition, and health. The aim of his research is to understand the mechanism of the molecular and cellular interactions between dietary factors and organisms. His current works pertains to the dietary regulation of the arachidonate cascade which is the biosynthetic pathway for the formation of a family of autacoids with diverse functions in cell signaling and other related metabolic pathways of essential fatty acids and membrane lipids. His focus has been on the regulation and the role of prostanoids during the changes in the life cycle of adipocytes whose changes are known to be important for understanding the mechanism leading to obesity and the associated diseases. As part of his PhD work, he demonstrated that the pretreatment of cultured preadipocytes with arachidonic acid or Omega-3 fatty acids during the differentiation phase of adipogenesis inhibits adipogenesis in the presence of 3-isobutyl-1-methylxanthine. He also analyzed and established that 11-Deoxy-11-methylene-prostaglandin (PG) D2 and PGD2 exert their anti-adipogenic effect principally through the mediation of PPARγ and CRTH2 receptors during the differentiation phase of adipogenesis. He is also a part-time lecturer at the Department of Mathematics and Science, University of Cape Coast lecturing Biology courses in the Switch programmes. He has published some of his works in international journals and presented some in both national and international scientific conferences.

    Publications (Peer Reviewed)

  • Nartey, M.N.N., Shimizu, H., Sugiyama, H., Higa, M., Syeda, P.K., Nishimura, K., Jisaka, M., Yokota, K. (2023). Eicosapentaenoic acid induces the Inhibition of adipogenesis by reducing the effect of PPARγ Activator and mediating PKA Activation and increased COX-2 expression in 3T3-L1 cells at the differentiation stage. Life. 13, 1704. https://doi.org/10.3390/life13081704
  • Nartey, M. N. N., Jisaka, M., Syeda, P. K., Nishimura, K., Shimizu, H., Yokota, K. (2023). Arachidonic acid added during the differentiation phase of 3T3-L1 cells exerts anti-adipogenic effect by reducing the effects of pro-adipogenic prostaglandins. Life. 13; 367. https://doi.org/10.3390/life13020367
  • Nartey, M. N. N., Jisaka, M., Syeda, P. K., Nishimura, K., Shimizu, H., Yokota, K. (2023). Prostaglandin D2 added during the differentiation of 3T3-L1 cells suppresses adipogenesis via dysfunction of D-prostanoid receptor P1 and P2. Life. 13; 370. https://doi.org/10.3390/life13020370
  • Rahman, M. S., Syeda, P. K., Nartey, M. N. N., Chowdhury, M. M. I., Shimizu, H., Nishimura, K., Jisaka, M., Shono, F., Yokota, K. (2018). Comparison of pro-adipogenic effects between prostaglandin (PG) D2 and its stable, isosteric analogue, 11-deoxy-11-methylene-PGD2, during the maturation phase of cultured adipocytes. Prostaglandins and Other Lipid Mediators. 39; 71-79. https://doi.org/10.1016/j.prostaglandins.2018.10.006
  • Khan, F., Syeda, P. K., Nartey, M. N. N., Rahman, M. S., Islam, M. S., Nishimura, K., Jisaka, M., Shono, F., & Yokota, K. (2016). Pretreatment of cultured preadipocytes with arachidonic acid during the differentiation phase without a cAMP-elevating agent enhances fat storage after the maturation phase. Prostaglandins and Other Lipid Mediators. 123; 16-27. https://doi.org/10.1016/j.prostaglandins.2016.02.003
  • Khan, F., Syeda, P. K., Nartey, M. N. N., Rahman, M. S., Islam, M. S., Nishimura, K., Jisaka, M., Shono, F., & Yokota, K. (2016). Stimulation of fat storage by prostacyclin and selective agonists of prostanoid IP receptor during the maturation phase of cultured adipocytes. Cytotechnology. 1-13. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5101312/